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Article

Quantitative Fitness Analysis Identifies exo1∆ and Other Suppressors or Enhancers of Telomere Defects in Schizosaccharomyces pombe.

PloS one - 1 Jan 2015

Narayanan Siddharth, Dubarry Marion, Lawless Conor, Banks A Peter, Wilkinson Darren J, Whitehall Simon K, Lydall David

Abstract excerpt

Synthetic genetic array (SGA) has been successfully used to identify genetic interactions in S. cerevisiae and S. pombe. In S. pombe, SGA methods use either cycloheximide (C) or heat shock (HS) to select double mutants before measuring colony size as a surrogate for fitness. Quantitative Fitness Analysis (QFA) is a different method for determining fitness of microbial strains. In QFA, liquid cultures are spotted...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Regulatory Sequences, Nucleic Acid

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Source

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Identifiers

PMID: 26168240
DOI: 10.1371/journal.pone.0132240
PMCID: PMC4500466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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