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Article

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi.

Development (Cambridge, England) - 1 May 2011

Fernandez-Valdivia Rodrigo, Takeuchi Hideyuki, Samarghandi Amin, Lopez Mario, Leonardi Jessica, Haltiwanger Robert S, Jafar-Nejad Hamed

Abstract excerpt

Protein O-glucosylation is a conserved post-translational modification that occurs on epidermal growth factor-like (EGF) repeats harboring the C(1)-X-S-X-P-C(2) consensus sequence. The Drosophila protein O-glucosyltransferase (Poglut) Rumi regulates Notch signaling, but the contribution of protein O-glucosylation to mammalian Notch signaling and embryonic development is not known. Here, we show that mouse Rumi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21490058
DOI: 10.1242/dev.060020
PMCID: PMC3082299

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi.PMID 21490058Read ↗

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