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Article

Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.

Cell - 25 Jan 2008

Acar Melih, Jafar-Nejad Hamed, Takeuchi Hideyuki, Rajan Akhila, Ibrani Dafina, Rana Nadia A, Pan Hongling, Haltiwanger Robert S, Bellen Hugo J

Abstract excerpt

Notch signaling is broadly used to regulate cell-fate decisions. We have identified a gene, rumi, with a temperature-sensitive Notch phenotype. At 28 degrees C-30 degrees C, rumi clones exhibit a full-blown loss of Notch signaling in all tissues tested. However, at 18 degrees C only a mild Notch...

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Source

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Identifiers

PMID: 18243100
DOI: 10.1016/j.cell.2007.12.016
PMCID: PMC2275919

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18243100-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.PMID 18243100Read ↗

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