Article
Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.
Cell - 25 Jan 2008
Acar Melih, Jafar-Nejad Hamed, Takeuchi Hideyuki, Rajan Akhila, Ibrani Dafina, Rana Nadia A, Pan Hongling, Haltiwanger Robert S, Bellen Hugo J
Abstract excerpt
Notch signaling is broadly used to regulate cell-fate decisions. We have identified a gene, rumi, with a temperature-sensitive Notch phenotype. At 28 degrees C-30 degrees C, rumi clones exhibit a full-blown loss of Notch signaling in all tissues tested. However, at 18 degrees C only a mild Notch phenotype is evident. In vivo analyses reveal that the target of Rumi is the extracellular domain of Notch. Notch...
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