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Article

A notch sweeter.

Cell - 25 Jan 2008

Irvine Kenneth D

Abstract excerpt

Notch is a key signaling protein mediating cell-fate decisions during development. In this issue, Acar et al. (2008) describe a new gene called rumi that is required for Notch signaling in Drosophila. This gene encodes an O-glucosyltransferase that attaches glucose sugars to serine residues in the multiple EGF domains of the extracellular region of Notch. This modification by Rumi likely influences Notch folding...

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Source

Identifiers

PMID: 18243091
DOI: 10.1016/j.cell.2008.01.005

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A notch sweeter.PMID 18243091Read ↗

Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.Semantic proximity Read ↗

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi.Semantic proximity Read ↗

Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling.Semantic proximity Read ↗

Structure-function analysis of Drosophila Notch using genomic rescue transgenes.Semantic proximity Read ↗

Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase.Semantic proximity Read ↗

Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations.Semantic proximity Read ↗

Negative regulation of notch signaling by xylose.Semantic proximity Read ↗

Regulation of Notch signaling by glycosylation.Semantic proximity Read ↗

Regulation of notch signaling by o-linked fucose.Semantic proximity Read ↗

Identification of a new allele of O-fucosyltransferase 1 involved in Drosophila intestinal stem cell regulation.Semantic proximity Read ↗

Two pathways for importing GDP-fucose into the endoplasmic reticulum lumen function redundantly in the O-fucosylation of Notch in Drosophila.Semantic proximity Read ↗

Notch signaling in development and disease.Semantic proximity Read ↗

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