Article
Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2.
PLoS genetics - 1 Oct 2015
Ramkumar Nitya, Harvey Beth M, Lee Jeffrey D, Alcorn Heather L, Silva-Gagliardi Nancy F, McGlade C Jane, Bestor Timothy H, Wijnholds Jan, Haltiwanger Robert S, Anderson Kathryn V
Abstract excerpt
Crumbs family proteins are apical transmembrane proteins with ancient roles in cell polarity. Mouse Crumbs2 mutants arrest at midgestation with abnormal neural plate morphology and a deficit of mesoderm caused by defects in gastrulation. We identified an ENU-induced mutation, wsnp, that phenocopies the Crumbs2 null phenotype. We show that wsnp is a null allele of Protein O-glucosyltransferase 1 (Poglut1), which...
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