Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Negative regulation of notch signaling by xylose.

PLoS genetics - 1 Jun 2013

Lee Tom V, Sethi Maya K, Leonardi Jessica, Rana Nadia A, Buettner Falk F R, Haltiwanger Robert S, Bakker Hans, Jafar-Nejad Hamed

Abstract excerpt

The Notch signaling pathway controls a large number of processes during animal development and adult homeostasis. One of the conserved post-translational modifications of the Notch receptors is the addition of an O-linked glucose to epidermal growth factor-like (EGF) repeats with a C-X-S-X-(P/A)-C motif by Protein O-glucosyltransferase 1 (POGLUT1; Rumi in Drosophila). Genetic experiments in flies and mice, and in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila Proteins
Share to Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucose

Share to Glucosyltransferases

Share to Pentosyltransferases

Share to Receptors, Notch

Share to Repetitive Sequences, Amino Acid

Share to Xylose

Source

Open in PubMed Open full text

Identifiers

PMID: 23754965
DOI: 10.1371/journal.pgen.1003547
PMCID: PMC3675014

Genes

EGF
POGLUT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Negative regulation of notch signaling by xylose.PMID 23754965Read ↗

Regulation of Notch signaling by glycosylation.Semantic proximity Read ↗

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi.Semantic proximity Read ↗

Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling.Semantic proximity Read ↗

Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase.Semantic proximity Read ↗

A notch sweeter.Semantic proximity Read ↗

Roles of O-fucose glycans in notch signaling revealed by mutant mice.Semantic proximity Read ↗

Contribution of extracellular O-GlcNAc to the stability of folded epidermal growth factor-like domains and Notch1 trafficking.Semantic proximity Read ↗

Structure-function analysis of Drosophila Notch using genomic rescue transgenes.Semantic proximity Read ↗

Regulation of notch signaling by o-linked fucose.Semantic proximity Read ↗

Functional analysis of glycosylation using Drosophila melanogaster.Semantic proximity Read ↗

Drosophila O-GlcNAcase Mutants Reveal an Expanded Glycoproteome and Novel Growth and Longevity Phenotypes.Semantic proximity Read ↗

Wollknauel is required for embryo patterning and encodes the Drosophila ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.