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Article

Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling.

Development (Cambridge, England) - 1 Aug 2011

Leonardi Jessica, Fernandez-Valdivia Rodrigo, Li Yi-Dong, Simcox Amanda A, Jafar-Nejad Hamed

Abstract excerpt

Mutations in Drosophila rumi result in a temperature-sensitive loss of Notch signaling. Rumi is a protein O-glucosyltransferase that adds glucose to EGF repeats with a C-X-S-X-P-C consensus sequence. Eighteen of the 36 EGF repeats in the Drosophila Notch receptor contain the consensus O-glucosylation motif. However, the contribution of individual O-glucose residues on Notch to the regulation of Notch signaling is...

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Identifiers

PMID: 21771811
DOI: 10.1242/dev.068361
PMCID: PMC3143569

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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