What Have We Learned from Glycosyltransferase Knockouts in Mice?

doi:10.1016/j.jmb.2016.03.025

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Article

What Have We Learned from Glycosyltransferase Knockouts in Mice?

Journal of molecular biology - 14 Aug 2016

Stanley Pamela

Abstract excerpt

There are five major classes of glycan including N- and O-glycans, glycosaminoglycans, glycosphingolipids, and glycophosphatidylinositol anchors, all expressed at the molecular frontier of each mammalian cell. Numerous biological consequences of altering the expression of mammalian glycans are understood at a mechanistic level, but many more remain to be characterized. Mouse mutants with deleted, defective, or...

Topics

Animals
Glycosylation
Glycosyltransferases
Humans
Mice
Mice, Knockout
Mutation
Polysaccharides

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Identifiers

PMID: 27040397
DOI: 10.1016/j.jmb.2016.03.025
PMCID: PMC5532804

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