Article

The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice

2024-11-25

Abstract excerpt

Mutations in protein O -glucosyltransferase 1 ( POGLUT1 ) cause a recessive form of limb-girdle muscular dystrophy (LGMD-R21) associated with reduced satellite cell number and NOTCH1 signaling in adult patient muscles and impaired myogenic capacity of patient-derived muscle progenitors. However, the in vivo roles of POGLUT1 in the development, function, and maintenance of satellite cells are not well understood...

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Literature Corpus work: 55f8787e-e1ce-5227-b491-810cde984dfa
DOI: 10.1101/2024.11.25.625261

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