Article
Polymorphisms in the ABCB1 gene in phenobarbital responsive and resistant idiopathic epileptic Border Collies.
Journal of veterinary internal medicine - 1 Jan 2000
Alves L, Hülsmeyer V, Jaggy A, Fischer A, Leeb T, Drögemüller M
Abstract excerpt
BACKGROUND: Variation in the ABCB1 gene is believed to play a role in drug resistance in epilepsy. HYPOTHESIS/OBJECTIVES: Variation in the ABCB1 gene encoding the permeability-glycoprotein could have an influence on phenobarbital (PB) resistance, which occurs with high frequency in idiopathic epileptic Border Collies (BCs). ANIMALS: Two hundred and thirty-six client-owned BCs from Switzerland and Germany...
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