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Article

The prevalence of ABCB1:c.227_230delATAG mutation in affected dog breeds from European countries.

Research in veterinary science - 1 Jun 2016

Firdova Zuzana, Turnova Evelina, Bielikova Marcela, Turna Jan, Dudas Andrej

Abstract excerpt

Deletion of 4-base pairs in the canine ABCB1 (MDR1) gene, responsible for encoding P-glycoprotein, leads to nonsense frame-shift mutation, which causes hypersensitivity to macrocyclic lactones drugs (e.g. ivermectin). To date, at least 12 purebred dog breeds have been found to be affected by this mutation. The aim of this study was to update information about the prevalence of ABCB1 mutation (c.227_230delATAG) in...

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Source

Identifiers

PMID: 27234542
DOI: 10.1016/j.rvsc.2016.03.016

Genes

ABCB1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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