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Article

Association of ABCB1 genetic variants 3435C>T and 2677G>T to ABCB1 mRNA and protein expression in brain tissue from refractory epilepsy patients.

Epilepsia - 1 Sept 2008

Mosyagin Igor, Runge Uwe, Schroeder Henry W, Dazert Eike, Vogelgesang Silke, Siegmund Werner, Warzok Rolf W, Cascorbi Ingolf

Abstract excerpt

PURPOSE: There is evidence from studies in rodents that P-glycoprotein (P-gp) overexpression is implicated in the causation of refractory epilepsy. Genetic variants in the human ABCB1 (MDR1) gene were shown to affect the expression levels of the transporter in various tissues and to be associated with refractory epilepsy. However, the effect of the genetic variants on the P-gp level in epileptogenic brain tissue...

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Source

Identifiers

PMID: 18494787
DOI: 10.1111/j.1528-1167.2008.01661.x

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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