Article
ABCB1 c.-6-180T>G polymorphism and clinical risk factors in a multi-breed cohort of dogs with refractory idiopathic epilepsy.
Veterinary journal (London, England : 1997) - 1 Nov 2019
Gagliardo T, Gandini G, Gallucci A, Menchetti M, Bianchi E, Turba M E, Cauduro A, Corlazzoli D S, Gianni S, Baroni M, Bernardini M, Gentilini F
Abstract excerpt
Epilepsy is the most common chronic neurological disorder in dogs. Approximately 20-30% of dogs do not achieve satisfactory seizure control with two or more anti-epileptic drugs at appropriate dosages. This condition, defined as refractory epilepsy, is a multifactorial condition involving both acquired and genetic factors. The P glycoprotein might play and important role in the pathophysiological mechanism and it...
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