Article
Association between ABCB1 genotype and seizure outcome in Collies with epilepsy.
Journal of veterinary internal medicine - 1 Jan 2000
Muñana K R, Nettifee-Osborne J A, Bergman R L, Mealey K L
Abstract excerpt
BACKGROUND: Medically refractory seizures are an important problem in both humans and dogs with epilepsy. Altered expression of ABCB1, the gene encoding for p-glycoprotein (PGP), has been proposed to play a role in drug-resistant epilepsy. HYPOTHESIS: Heterogeneity of the ABCB1 gene is associated with seizure outcome in dogs with epilepsy. ANIMALS: Twenty-nine Collies with epilepsy being treated with...
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