Article
High frequency of a single nucleotide substitution (c.-6-180T>G) of the canine MDR1/ABCB1 gene associated with phenobarbital-resistant idiopathic epilepsy in Border Collie dogs.
Disease markers - 1 Jan 2013
Mizukami Keijiro, Yabuki Akira, Chang Hye-Sook, Uddin Mohammad Mejbah, Rahman Mohammad Mahbubur, Kushida Kazuya, Kohyama Moeko, Yamato Osamu
Abstract excerpt
A single nucleotide substitution (c.-6-180T>G) associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy. In the present study, a PCR-restriction fragment length polymorphism assay was developed for genotyping this mutation, and a genotyping survey was carried out in a population of 472 Border Collies in Japan to determine the...
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