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Article

Association of death receptor 4 variant (683A > C) with ovarian cancer risk in BRCA1 mutation carriers.

International journal of cancer - 15 Mar 2012

Dick Michelle G, Versmold Beatrix, Engel Christoph, Meindl Alfons, Arnold Norbert, Varon-Mateeva Raymonda, Sutter Christian, Niederacher Dieter, Deissler Helmut, Preisler-Adams Sabine, Kast Karin, Schäfer Dieter, Gadzicki Dorothea, Heinritz Wolfram, Wappenschmidt Barbara, Schmutzler Rita K

Abstract excerpt

Dysregulation of apoptosis plays an important role in carcinogenesis. Therefore, apoptosis-associated genes like the death receptor 4 (DR4, TRAIL-R1) are interesting candidates for modifying the penetrance of breast and ovarian cancer in carriers of BRCA1 and BRCA2 mutations. The DR-4 haplotype 626C-683C [626C > G, Thr209Arg (rs4871857) and 683A > C, Glu228Ala (rs17088993)] has recently been linked to an...

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Source

Identifiers

PMID: 21484799
DOI: 10.1002/ijc.26134

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of death receptor 4 variant (683A > C) with ovarian cancer risk in BRCA1 mutation carriers.PMID 21484799Read ↗

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