Article
The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study.
Breast cancer research and treatment - 1 Sept 2008
Frank Bernd, Rigas Sushila H, Bermejo Justo Lorenzo, Wiestler Miriam, Wagner Kerstin, Hemminki Kari, Reed Malcolm W, Sutter Christian, Wappenschmidt Barbara, Balasubramanian Sabapathy P, Meindl Alfons, Kiechle Marion, Bugert Peter, Schmutzler Rita K, Bartram Claus R, Justenhoven Christina, Ko Yon-Dschun, Brüning Thomas, Brauch Hiltrud, Hamann Ute, Pharoah Paul P D, Dunning Alison M, Pooley Karen A, Easton Douglas F, Cox Angela, Burwinkel Barbara
Abstract excerpt
A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921...
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