Article
Association of death receptor 4 haplotype 626C-683C with an increased breast cancer risk.
Carcinogenesis - 1 Nov 2005
Frank Bernd, Hemminki Kari, Shanmugam Kalai S, Meindl Alfons, Klaes Rüdiger, Schmutzler Rita K, Wappenschmidt Barbara, Untch Michael, Bugert Peter, Bartram Claus R, Burwinkel Barbara
Abstract excerpt
Dysregulation of apoptosis plays a crucial role in carcinogenesis. Tumour necrosis factor-related apoptosis-inducing ligand stimulates the extrinsic apoptotic pathway by binding to death receptor 4 (DR4). Thus, genetic alterations within the candidate tumour suppressor gene DR4 would be expected to provoke a deficient apoptotic signalling thereby facilitating the development of cancer. The DR4 variants Thr209Arg...
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