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Article

Genetic contribution of caspase-8 variants and haplotypes to breast cancer risk and prognosis: a case-control study in Iran.

BMC medical genomics - 4 Apr 2023

Afzaljavan Fahimeh, Vahednia Elham, Barati Bagherabad Matineh, Vakili Fatemeh, Moezzi Atefeh, Hosseini Azar, Homaei Shandiz Fatemeh, Kooshyar Mohammad Mahdi, Nassiri Mohammadreza, Pasdar Alireza

Abstract excerpt

PURPOSE: Multiple genome-wide and candidate-gene association studies have been conducted to search for common risk variants of breast cancer. Recent large meta-analyses and consolidating evidence have highlighted the role of the caspase-8 gene in breast cancer pathogenesis. Therefore, this study aimed to identify common variations and haplotypes associated with risk and overall survival of breast cancer with...

Topics

Female
Humans
Alleles
Breast Neoplasms
Case-Control Studies
Caspase 8
Genetic Predisposition to Disease
Genotype
Haplotypes
Iran

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Open in PubMed Open full text

Identifiers

PMID: 37016353
DOI: 10.1186/s12920-023-01484-0
PMCID: PMC10071634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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