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Article

Death receptor 4 variants and colorectal cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2006

Frank Bernd, Shanmugam Kalai Selvi, Beckmann Lars, Hemminki Kari, Brenner Hermann, Hoffmeister Michael, Chang-Claude Jenny, Burwinkel Barbara

Abstract excerpt

The tumor necrosis factor-related apoptosis-inducing ligand receptor modulates apoptotic response by binding to the proapoptotic death receptor 4 (DR4). Perturbed apoptosis due to missense alterations in the candidate tumor suppressor gene DR4 leads to deregulated cell proliferation and cancer predisposition. Recent studies have discussed the association of DR4 variants with cancer risk. We evaluated, for the...

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PMID: 17035413
DOI: 10.1158/1055-9965.EPI-06-0053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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