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Article

CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels.

Cancer prevention research (Philadelphia, Pa.) - 1 Jun 2011

Miliani de Marval Paula, Lutfeali Shazia, Jin Jane Y, Leshin Benjamin, Selim M Angelica, Zhang Jennifer Y

Abstract excerpt

CYLD has been recognized as a tumor suppressor due to its dominant genetic linkage to multiple types of epidermal tumors and a range of other cancers. The molecular mechanisms governing CYLD control of skin cancer are still unclear. Here, we showed that K14-driven epidermal expression of a patient-relevant and catalytically deficient CYLD truncated mutant (CYLD(m)) sensitized mice to skin tumor development in...

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Share to 9,10-Dimethyl-1,2-benzanthracene
Share to Deubiquitinating Enzyme CYLD

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to JNK Mitogen-Activated Protein Kinases

Share to Proto-Oncogene Proteins c-fos

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Share to Tetradecanoylphorbol Acetate

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Source

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Identifiers

PMID: 21478324
DOI: 10.1158/1940-6207.CAPR-10-0360
PMCID: PMC3107906

Genes

CYLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels.PMID 21478324Read ↗

CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways.Semantic proximity Read ↗

CYLD regulates keratinocyte differentiation and skin cancer progression in humansSemantic proximity Read ↗

An inactivating CYLD mutation promotes skin tumor progression by conferring enhanced proliferative, survival and angiogenic properties to epidermal cancer cells.Semantic proximity Read ↗

Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice.Semantic proximity Read ↗

Tumor Suppressor Function of CYLD in Nonmelanoma Skin CancerSemantic proximity Read ↗

Cylindromatosis and the <i>CYLD</i> gene: new lessons on the molecular principles of epithelial growth controlSemantic proximity Read ↗

Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation.Semantic proximity Read ↗

Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila.Semantic proximity Read ↗

Inactivation of the Tumor Suppressor CYLD Sensitizes Mice to Breast Cancer Development.Semantic proximity Read ↗

The tumour suppressor CYLD regulates the p53 DNA damage response.Semantic proximity Read ↗

CYLD-Mediated Signaling and DiseasesSemantic proximity Read ↗

Functional inactivation of CYLD promotes the metastatic potential of tumor epidermal cells.Semantic proximity Read ↗

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