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Article

CYLD regulates keratinocyte differentiation and skin cancer progression in humans

8 Sept 2011

Abstract excerpt

CYLD is a gene mutated in familial cylindromatosis and related diseases, leading to the development of skin appendages tumors. Although the deubiquitinase CYLD is a skin tumor suppressor, its role in skin physiology is unknown. Using skin organotypic cultures as experimental model to mimic human skin, we have found that CYLD acts as a regulator of epidermal differentiation in humans through the JNK signaling...

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Identifiers

PMID: 21900959
DOI: 10.1038/cddis.2011.82

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Related research

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CYLD regulates keratinocyte differentiation and skin cancer progression in humansPMID 21900959Read ↗

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