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Article

Inactivation of the Tumor Suppressor CYLD Sensitizes Mice to Breast Cancer Development.

Anticancer research - 1 May 2024

Pseftogas Athanasios, Xanthopoulos Konstantinos, Siasiaridis Athanasios, Poutahidis Theofilos, Gonidas Christos, Tsingotjidou Anastasia, Hatzivassiliou Eudoxia, Mosialos George

Abstract excerpt

BACKGROUND/AIM: Breast cancer is a leading cause of cancer-related deaths among women. Down-regulation of the tumor suppressor gene Cyld in breast cancer has been linked to a poor prognosis. This study investigated the role of Cyld in breast cancer using conditional mutant mouse models carrying a Cyld mutation, which inactivates the deubiquitinating activity of its protein product CYLD in mammary epithelial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38677721
DOI: 10.21873/anticanres.16990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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