Article
CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways.
The Journal of investigative dermatology - 1 Jan 2013
Ke Hengning, Augustine Christina K, Gandham Vineela D, Jin Jane Y, Tyler Douglas S, Akiyama Steven K, Hall Russell P, Zhang Jennifer Y
Abstract excerpt
The molecular mechanisms mediating cylindromatosis (CYLD) tumor suppressor function appear to be manifold. Here, we demonstrate that, in contrast to the increased levels of phosphorylated c-Jun NH(2)-terminal kinase (pJNK), CYLD was decreased in a majority of the melanoma cell lines and tissues examined. Exogenous expression of CYLD but not its catalytically deficient mutant markedly inhibited melanoma cell...
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