Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor Suppressor Function of CYLD in Nonmelanoma Skin Cancer

1 Jan 2011

Abstract excerpt

Ubiquitin and ubiquitin-related proteins posttranslationally modify substrates, and thereby alter the functions of their targets. The ubiquitination process is involved in various physiological responses, and dysregulation of components of the ubiquitin system has been linked to many diseases including skin cancer. The ubiquitin pathways activated among skin cancers are highly diverse and may reflect the various...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Hedgehog Signaling Pathway Studies
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22235375
DOI: 10.1155/2011/614097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor Suppressor Function of CYLD in Nonmelanoma Skin CancerPMID 22235375Read ↗

CYLD regulates keratinocyte differentiation and skin cancer progression in humansSemantic proximity Read ↗

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.Semantic proximity Read ↗

CYLD Alterations in the Tumorigenesis and Progression of Human Papillomavirus–Associated Head and Neck CancersSemantic proximity Read ↗

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate Notch signallingSemantic proximity Read ↗

Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation.Semantic proximity Read ↗

Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice.Semantic proximity Read ↗

Cylindromatosis and the <i>CYLD</i> gene: new lessons on the molecular principles of epithelial growth controlSemantic proximity Read ↗

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.Semantic proximity Read ↗

CYLD-Mediated Signaling and DiseasesSemantic proximity Read ↗

CYLD Limits Neutrophil-Driven Psoriatic InflammationSemantic proximity Read ↗

CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels.Semantic proximity Read ↗

The Tumor Suppressor CYLD Interacts with TRIP and Regulates Negatively Nuclear Factor κB Activation by Tumor Necrosis FactorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.