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Article

The tumour suppressor CYLD regulates the p53 DNA damage response.

Nature communications - 26 Aug 2016

Fernández-Majada Vanesa, Welz Patrick-Simon, Ermolaeva Maria A, Schell Michael, Adam Alexander, Dietlein Felix, Komander David, Büttner Reinhard, Thomas Roman K, Schumacher Björn, Pasparakis Manolis

Abstract excerpt

The tumour suppressor CYLD is a deubiquitinase previously shown to inhibit NF-κB, MAP kinase and Wnt signalling. However, the tumour suppressing mechanisms of CYLD remain poorly understood. Here we show that loss of CYLD catalytic activity causes impaired DNA damage-induced p53 stabilization and activation in epithelial cells and sensitizes mice to chemical carcinogen-induced intestinal and skin tumorigenesis....

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Source

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Identifiers

PMID: 27561390
DOI: 10.1038/ncomms12508
PMCID: PMC5007442

Genes

CYLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The tumour suppressor CYLD regulates the p53 DNA damage response.PMID 27561390Read ↗

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