Article
Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice.
The Journal of clinical investigation - 1 Nov 2006
Zhang Jun, Stirling Brigid, Temmerman Stephane T, Ma Chi A, Fuss Ivan J, Derry Jonathan M J, Jain Ashish
Abstract excerpt
Cylindromatosis (CYLD) is a deubiquitinating enzyme that is altered in patients with familial cylindromatosis, a condition characterized by numerous benign adnexal tumors. However, the regulatory function of CYLD remains unsettled. Here we show that the development of B cells, T cells, and myeloid cells was unaffected in CYLD-deficient mice, but that the activation of these cells with mediators of innate and...
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