Article
An inactivating CYLD mutation promotes skin tumor progression by conferring enhanced proliferative, survival and angiogenic properties to epidermal cancer cells.
Oncogene - 16 Dec 2010
Alameda J P, Moreno-Maldonado R, Navarro M, Bravo A, Ramírez A, Page A, Jorcano J L, Fernández-Aceñero M J, Casanova M L
Abstract excerpt
In this study, we demonstrate that the expression in tumorigenic epidermal cells of a catalytically inactive form of CYLD (CYLD(C/S)) that mimics the identified mutations of cyld in human tumors and competes with the endogenous CYLD results in enhanced cell proliferation and inhibition of apoptosis; it also stimulates cell migration and induces the expression of angiogenic factors, including vascular endothelial...
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