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Article

CYLD-Mediated Signaling and Diseases

27 Oct 2014

Abstract excerpt

The conserved cylindromatosis (CYLD) codes for a deubiquitinating enzyme and is a crucial regulator of diverse cellular processes such as immune responses, inflammation, death, and proliferation. It directly regulates multiple key signaling cascades, such as the Nuclear Factor kappa B [NFkB] and the Mitogen-Activated Protein Kinase (MAPK) pathways, by its catalytic activity on polyubiquitinated key intermediates....

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PMID: 25342597
DOI: 10.2174/1389450115666141024152421

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