Article
Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1.
The Journal of clinical investigation - 1 May 2018
Martin Maureen P, Naranbhai Vivek, Shea Patrick R, Qi Ying, Ramsuran Veron, Vince Nicolas, Gao Xiaojiang, Thomas Rasmi, Brumme Zabrina L, Carlson Jonathan M, Wolinsky Steven M, Goedert James J, Walker Bruce D, Segal Florencia P, Deeks Steven G, Haas David W, Migueles Stephen A, Connors Mark, Michael Nelson, Fellay Jacques, Gostick Emma, Llewellyn-Lacey Sian, Price David A, Lafont Bernard A, Pymm Phillip, Saunders Philippa M, Widjaja Jacqueline, Wong Shu Cheng, Vivian Julian P, Rossjohn Jamie, Brooks Andrew G, Carrington Mary
Abstract excerpt
HLA-B*57 control of HIV involves enhanced CD8+ T cell responses against infected cells, but extensive heterogeneity exists in the level of HIV control among B*57+ individuals. Using whole-genome sequencing of untreated B*57+ HIV-1-infected controllers and noncontrollers, we identified a single variant (rs643347A/G) encoding an isoleucine-to-valine substitution at position 47 (I47V) of the inhibitory killer cell...
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