Article
COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome.
Synapse (New York, N.Y.) - 1 Sept 2011
Boot Erik, Booij Jan, Zinkstok Janneke R, Baas Frank, Swillen Ann, Owen Michael J, Murphy Declan G, Murphy Kieran C, Linszen Don H, Van Amelsvoort Thérèse A
Abstract excerpt
Although catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val(158) Met) influences striatal D(2/3) R binding ratios (D(2/3) R BP(ND) ) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission...
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