Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of COMT genotype on behavioral symptomatology in the 22q11.2 Deletion Syndrome.

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence - 1 Feb 2005

Bearden Carrie E, Jawad Abbas F, Lynch David R, Monterossso John R, Sokol Set, McDonald-McGinn Donna M, Saitta Sulagna C, Harris Stacy E, Moss Edward, Wang Paul P, Zackai Elaine, Emanuel Beverly S, Simon Tony J

Abstract excerpt

The 22q11.2 Deletion Syndrome (DiGeorge/velocardiofacial syndrome) is associated with elevated rates of psychosis, and is also characterized by severe attentional difficulties and executive dysfunction. Behavioral manifestations of this syndrome could result from haploinsufficiency of the catechol-O-methyltransferase (COMT) gene, located within the 22q11 region. The goal of the present study was to examine COMT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child Behavior Disorders

Share to Chromosomes, Human, Pair 22

Share to DiGeorge Syndrome

Share to Gene Deletion

Share to Polymorphism, Genetic

Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 15846854
DOI: 10.1080/09297040590911239
PMCID: PMC2810976

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of COMT genotype on behavioral symptomatology in the 22q11.2 Deletion Syndrome.PMID 15846854Read ↗

Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome.Semantic proximity Read ↗

Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome.Semantic proximity Read ↗

No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome.Semantic proximity Read ↗

Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome.Semantic proximity Read ↗

Association of the low-activity COMT 158Met allele with ADHD and OCD in subjects with velocardiofacial syndrome.Semantic proximity Read ↗

COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome.Semantic proximity Read ↗

Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes.Semantic proximity Read ↗

Catechol-O-methyl transferase and expression of schizophrenia in 73 adults with 22q11 deletion syndrome.Semantic proximity Read ↗

COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome.Semantic proximity Read ↗

Effects of a functional COMT polymorphism on brain anatomy and cognitive function in adults with velo-cardio-facial syndromeSemantic proximity Read ↗

Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndromeSemantic proximity Read ↗

IQ and hemizygosity for the Val158 Met functional polymorphism of COMT in 22q11DS.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.