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Article

Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome.

Clinical genetics - 1 Mar 2006

Shashi V, Keshavan M S, Howard T D, Berry M N, Basehore M J, Lewandowski E, Kwapil T R

Abstract excerpt

Chromosome 22q11.2 deletion syndrome (22q11DS) is a common microdeletion syndrome associated with a markedly elevated risk of schizophrenia in adulthood. Cognitive impairments such as a low IQ and deficits in attention and executive function are common in childhood. The catechol O-methyltransferase (COMT) gene maps within the deleted region and is involved in the degradation of dopamine, a neurotransmitter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16542388
DOI: 10.1111/j.1399-0004.2006.00569.x

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome.PMID 16542388Read ↗

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COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome.Semantic proximity Read ↗

COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome.Semantic proximity Read ↗

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Effects of COMT genotype on behavioral symptomatology in the 22q11.2 Deletion Syndrome.Semantic proximity Read ↗

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Genes, cognition and brain through a COMT lens.Semantic proximity Read ↗

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