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Article

Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome.

The American journal of psychiatry - 1 Sept 2004

Bearden Carrie E, Jawad Abbas F, Lynch David R, Sokol Set, Kanes Steven J, McDonald-McGinn Donna M, Saitta Sulagna C, Harris Stacy E, Moss Edward, Wang Paul P, Zackai Elaine, Emanuel Beverly S, Simon Tony J

Abstract excerpt

OBJECTIVE: The 22q11.2 deletion syndrome (DiGeorge/velocardiofacial syndrome) is associated with attentional problems and executive dysfunction, and is one of the highest known risk factors for schizophrenia. These behavioral manifestations of 22q11.2 deletion syndrome could result from haploinsufficiency of the catechol O-methyltransferase (COMT) gene, located within the 22q11 region. The goal of the present...

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Source

Identifiers

PMID: 15337663
DOI: 10.1176/appi.ajp.161.9.1700

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome.PMID 15337663Read ↗

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No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome.Semantic proximity Read ↗

COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome.Semantic proximity Read ↗

Executive functions and memory abilities in children with 22q11.2 deletion syndrome.Semantic proximity Read ↗

Effects of a functional COMT polymorphism on brain anatomy and cognitive function in adults with velo-cardio-facial syndromeSemantic proximity Read ↗

A gender-moderated effect of a functional COMT polymorphism on prefrontal brain morphology and function in velo-cardio-facial syndrome (22q11.2 deletion syndrome).Semantic proximity Read ↗

Catechol-O-methyl transferase and expression of schizophrenia in 73 adults with 22q11 deletion syndrome.Semantic proximity Read ↗

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Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome.Semantic proximity Read ↗

IQ and hemizygosity for the Val158 Met functional polymorphism of COMT in 22q11DS.Semantic proximity Read ↗

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