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Article

COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET.

Molecular psychiatry - 1 Aug 2008

Slifstein M, Kolachana B, Simpson E H, Tabares P, Cheng B, Duvall M, Frankle W Gordon, Weinberger D R, Laruelle M, Abi-Dargham A

Abstract excerpt

A common polymorphism (val158met) in the gene encoding catechol-O-methyltransferase (COMT) has been shown to affect dopamine (DA) tone in cortex and cortical functioning. D1 receptors are the main DA receptors in the cortex, and studies have shown that decreased levels of cortical DA are associat...

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Source

Identifiers

PMID: 18317466
DOI: 10.1038/mp.2008.19

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18317466-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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