Article
COMT Val108/158Met genotype affects the mu-opioid receptor system in the human brain: evidence from ligand-binding, G-protein activation and preproenkephalin mRNA expression.
NeuroImage - 15 Oct 2005
Berthele Achim, Platzer Stefan, Jochim Burkard, Boecker Henning, Buettner Andreas, Conrad Bastian, Riemenschneider Matthias, Toelle Thomas R
Abstract excerpt
Recent data from [(11)C]carfentanil ligand-PET indicate that in the human brain, the availability of mu-opioid (MOP) receptor binding sites is affected by the Val(108/158)Met polymorphism of the catechol-O-methyltransferase (COMT) gene. This prompted us to validate the impact of COMT Val(108/158)Met on MOP receptors in human post-mortem brain. [(3)H]DAMGO receptor autoradiography was performed in frontal cortex,...
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