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Article

COMT Val158Met genotype does not alter cortical or striatal dopamine D2 receptor availability in vivo.

Molecular imaging and biology - 1 Apr 2010

Hirvonen Mika M, Någren Kjell, Rinne Juha O, Pesonen Ullamari, Vahlberg Tero, Hagelberg Nora, Hietala Jarmo

Abstract excerpt

PURPOSE: Catechol-O-methyl transferase (COMT) is a pivotal regulator of brain dopamine function with a region-specific role. COMT is important in dopamine elimination in the prefrontal cortex, whereas dopamine reuptake is the main mechanism for synaptic removal of dopamine in the striatum. We stu...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19795175
DOI: 10.1007/s11307-009-0257-5

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19795175-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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COMT Val158Met genotype does not alter cortical or striatal dopamine D2 receptor availability in vivo.PMID 19795175Read ↗

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Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects.Semantic proximity Read ↗

COMT genotype is associated with differential expression of muscarinic M1 receptors in human cortex.Semantic proximity Read ↗

COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review.Semantic proximity Read ↗

Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype.Semantic proximity Read ↗

No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome.Semantic proximity Read ↗

A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) genotypes are associated with varying soluble, but not membrane-bound COMT protein in the human prefrontal cortex.Semantic proximity Read ↗

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