Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proofreading deficiency of Pol I increases the levels of spontaneous rpoB mutations in E. coli.

Mutation research - 1 Jul 2011

Makiela-Dzbenska K, Jonczyk P, Schaaper R M, Fijalkowska I J

Abstract excerpt

The fidelity role of DNA polymerase I in chromosomal DNA replication in E. coli was investigated using the rpoB forward target. These experiments indicated that in a strain carrying a proofreading-exonuclease-defective form of Pol I (polAexo mutant) the frequency of rpoB mutations increased by about 2-fold, consistent with a model that the fidelity of DNA polymerase I is important in controlling the overall...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Bacterial
Share to DNA-Directed RNA Polymerases
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Polymerase I

Share to DNA Replication

Share to Drug Resistance, Bacterial

Share to Escherichia coli Proteins

Share to Rifampin

Source

Open in PubMed Open full text

Identifiers

PMID: 21459099
DOI: 10.1016/j.mrfmmm.2011.03.011
PMCID: PMC3163159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proofreading deficiency of Pol I increases the levels of spontaneous rpoB mutations in E. coli.PMID 21459099Read ↗

Mutants in the Exo I motif of Escherichia coli dnaQ: defective proofreading and inviability due to error catastrophe.Semantic proximity Read ↗

Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I.Semantic proximity Read ↗

Mutants of Escherichia coli with increased fidelity of DNA replication.Semantic proximity Read ↗

The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I.Semantic proximity Read ↗

Spontaneous mutation in Escherichia coli containing the dnaE911 DNA polymerase antimutator allele.Semantic proximity Read ↗

Fidelity and error specificity of the alpha catalytic subunit of Escherichia coli DNA polymerase III.Semantic proximity Read ↗

DNA polymerase II as a fidelity factor in chromosomal DNA synthesis in Escherichia coli.Semantic proximity Read ↗

In vivo mutagenesis by Escherichia coli DNA polymerase I. Ile(709) in motif A functions in base selection.Semantic proximity Read ↗

Mutagenic cost of ribonucleotides in bacterial DNA.Semantic proximity Read ↗

Fidelity of DNA replication-a matter of proofreading.Semantic proximity Read ↗

Purification and properties of wild-type and exonuclease-deficient DNA polymerase II from Escherichia coli.Semantic proximity Read ↗

DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.