Mutants of Escherichia coli with increased fidelity of DNA replication.

doi:10.1093/genetics/134.4.1023

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Article

Mutants of Escherichia coli with increased fidelity of DNA replication.

Genetics - 1 Aug 1993

Fijalkowska I J, Dunn R L, Schaaper R M

Abstract excerpt

To improve our understanding of the role of DNA replication fidelity in mutagenesis, we undertook a search for Escherichia coli antimutator strains with increased fidelity of DNA replication. The region between 4 and 5 min of the E. coli chromosome was mutagenized using localized mutagenesis mediated by bacteriophage P1. This region contains the dnaE and dnaQ genes, which encode, respectively, the DNA polymerase...

Topics

Bacterial Proteins
Chromosome Mapping
DNA Polymerase III
DNA Replication
DNA, Bacterial
Escherichia coli
Escherichia coli Proteins
Genetic Complementation Test
Mutagenesis
Mutation
Phosphoric Monoester Hydrolases
Pyrophosphatases
SOS Response, Genetics

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Identifiers

PMID: 8375645
DOI: 10.1093/genetics/134.4.1023
PMCID: PMC1205570

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