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Article

βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.

Cell cycle (Georgetown, Tex.) - 15 Apr 2011

Sahasrabuddhe Anagh A, Dimri Manjari, Bommi Prashant V, Dimri Goberdhan P

Abstract excerpt

The polycomb group protein BMI1 has been linked to proliferation, senescence, cancer progression and stem cell phenotype. At present, very little is known about its regulation. Here, we report that BMI1 contains a functional recognition motif for the F box protein βTrCP, which regulates ubiquitination and proteasome-mediated degradation of various proteins. We show that overexpression of wild-type βTrCP but not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21430439
DOI: 10.4161/cc.10.8.15372
PMCID: PMC3117138

Genes

BMI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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