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Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain

22 Jun 2010

Abstract excerpt

BACKGROUND: The polycomb group (PcG) protein BMI1 is an important regulator of development. Additionally, aberrant expression of BMI1 has been linked to cancer stem cell phenotype and oncogenesis. In particular, its overexpression has been found in several human malignancies including breast cancer. Despite its established role in stem cell maintenance, cancer and development, at present not much is known about...

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PMID: 20569464
DOI: 10.1186/1476-4598-9-158

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