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Article

The characteristics and roles of β‐TrCP1/2 in carcinogenesis

6 Oct 2020

Abstract excerpt

β‐transducin repeat‐containing protein (β‐TrCP), one of the well‐characterized F‐box proteins, acts as a substrate receptor and constitutes an active SCF β‐TrCP E3 ligase with a scaffold protein CUL1, a RING protein RBX1, and an adaptor protein SKP1. β‐TrCP plays a critical role in the regulation of various physiological and pathological processes, including signal transduction, cell cycle progression, cell...

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PMID: 33021036
DOI: 10.1111/febs.15585

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