Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A positive feedback loop regulates the expression of polycomb group protein BMI1 via WNT signaling pathway.

The Journal of biological chemistry - 1 Feb 2013

Cho Joon-Ho, Dimri Manjari, Dimri Goberdhan P

Abstract excerpt

Polycomb group protein BMI1 plays an important role in cellular homeostasis by maintaining a balance between proliferation and senescence. It is often overexpressed in cancer cells and is required for self-renewal of stem cells. At present, very little is known about the signaling pathways that regulate the expression of BMI1. Here, we report that BMI1 autoactivates its own promoter via an E-box present in its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Feedback, Physiological
Share to Intercellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplastic Stem Cells

Share to Polycomb-Group Proteins

Share to Polycomb Repressive Complex 1

Share to Proto-Oncogene Proteins c-myc

Share to Up-Regulation

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 23239878
DOI: 10.1074/jbc.M112.422931
PMCID: PMC3561559

Genes

BMI1
DKK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A positive feedback loop regulates the expression of polycomb group protein BMI1 via WNT signaling pathway.PMID 23239878Read ↗

BMI-1, a promising therapeutic target for human cancerSemantic proximity Read ↗

BMI1: A Biomarker of Hematologic MalignanciesSemantic proximity Read ↗

Loss of the human polycomb group protein BMI1 promotes cancer-specific cell deathSemantic proximity Read ↗

BMI1 as a novel target for drug discovery in cancerSemantic proximity Read ↗

Polycomb group protein Bmi1 expression in colon cancers predicts the survivalSemantic proximity Read ↗

BMI-1 Promotes Ewing Sarcoma Tumorigenicity Independent of <i>CDKN2A</i> RepressionSemantic proximity Read ↗

Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domainSemantic proximity Read ↗

Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity.Semantic proximity Read ↗

βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.Semantic proximity Read ↗

Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1Semantic proximity Read ↗

Role of the polycomb group gene BMI1 in normal and leukemic hematopoietic stem and progenitor cells.Semantic proximity Read ↗

Identification and Characterization of Bmi-1-responding Element within the Human p16 Promoter*Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.