Article
The F-box protein β-TrCP promotes ubiquitination of TRF1 and regulates the ALT-associated PML bodies formation in U2OS cells.
Biochemical and biophysical research communications - 17 May 2013
Wang Chong, Xiao Haowen, Ma Jie, Zhu Yuanyuan, Yu Jian, Sun Ling, Sun Hui, Liu Yanfang, Jin Changjiang, Huang He
Abstract excerpt
The telomeric repeat binding protein 1 (TRF1) is a major factor of the mammalian telosome/shelterin and negatively regulates telomere length by inhibiting access of telomerase at telomere termini in telomerase-positive cells. In telomerase-negative cancer cells, TRF1 also plays a critical role in the mechanism called alternative lengthening of telomeres (ALT) and is essential for formation of the ALT-associated...
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