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Article

BMI-1, a promising therapeutic target for human cancer

11 Jun 2015

Abstract excerpt

oncogene is a member of the polycomb-group gene family and a transcriptional repressor. Overexpression of BMI-1 has been identified in various human cancer tissues and is known to be involved in cancer cell proliferation, cell invasion, distant metastasis, chemosensitivity and patient survival. Accumulating evidence has revealed that BMI-1 is also involved in the regulation of self-renewal, differentiation and...

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Identifiers

PMID: 26622537
DOI: 10.3892/ol.2015.3361

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