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Article

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo.

Developmental cell - 1 Jun 2003

Guardavaccaro Daniele, Kudo Yasusei, Boulaire Jérôme, Barchi Marco, Busino Luca, Donzelli Maddalena, Margottin-Goguet Florence, Jackson Peter K, Yamasaki Lili, Pagano Michele

Abstract excerpt

SCF ubiquitin ligases, composed of three major subunits, Skp1, Cul1, and one of many F box proteins (Fbps), control the proteolysis of important cellular regulators. We have inactivated the gene encoding the Fbp beta-Trcp1 in mice. beta-Trcp1(-/-) males show reduced fertility correlating with an accumulation of methaphase I spermatocytes. beta-Trcp1(-/-) MEFs display a lengthened mitosis, centrosome...

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Identifiers

PMID: 12791266
DOI: 10.1016/s1534-5807(03)00154-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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