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Article

BMI1 as a novel target for drug discovery in cancer

15 Jun 2011

Abstract excerpt

Growing evidence has demonstrated that clonogenic cancer stem (initiating) cells are responsible for tumor regrowth and disease relapse. Bmi-1 plays a critical role in the self-renewal of adult stem cells. The Bmi-1 protein is elevated in many types of cancers, and experimental reduction of Bmi-1 protein levels by small interfering RNA (siRNA) causes apoptosis and/or senescence in tumor cells in vitro and...

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PMID: 21678481
DOI: 10.1002/jcb.23234

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