Article
Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990
Howe J A, Mymryk J S, Egan C, Branton P E, Bayley S T
Abstract excerpt
Previous work has suggested that oncogenic transformation by the E1A gene products of adenovirus type 5 may be mediated through interactions with at least two cellular proteins, the 105-kDa product of the retinoblastoma growth suppressor gene (p105-Rb) and a 300-kDa protein (p300). By using viral...
Topics
- Adenovirus Early Proteins
- Adenoviruses, Human
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- DNA Replication
- DNA-Binding Proteins
- Exons
- Humans
- Molecular Weight
- Mutation
- Oncogene Proteins, Viral
- Phosphoproteins
- Plasmids
- Proteins
- RNA, Messenger
- Retinoblastoma Protein
- Thymidine