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Article

Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990

Howe J A, Mymryk J S, Egan C, Branton P E, Bayley S T

Abstract excerpt

Previous work has suggested that oncogenic transformation by the E1A gene products of adenovirus type 5 may be mediated through interactions with at least two cellular proteins, the 105-kDa product of the retinoblastoma growth suppressor gene (p105-Rb) and a 300-kDa protein (p300). By using viral mutants, we now show that the induction of cellular DNA synthesis in quiescent cells by E1A differs from...

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Identifiers

PMID: 2143024
DOI: 10.1073/pnas.87.15.5883
PMCID: PMC54433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis.PMID 2143024Read ↗

Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity.Semantic proximity Read ↗

Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growthSemantic proximity Read ↗

Functional interactions within adenovirus E1A protein complexes.Semantic proximity Read ↗

Complementary functions of E1a conserved region 1 cooperate with conserved region 3 to activate adenovirus serotype 5 early promoters.Semantic proximity Read ↗

The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains.Semantic proximity Read ↗

Adenovirus E1A-p105(Rb) protein interactions play a direct role in the initiation but not the maintenance of the rodent cell transformed phenotype.Semantic proximity Read ↗

Transactivation of the p53 oncogene by E1a gene products.Semantic proximity Read ↗

Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis.Semantic proximity Read ↗

Multiple pathways for gene activation in rodent cells by the smaller adenovirus 5 E1A protein and their relevance to growth and transformation.Semantic proximity Read ↗

Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering.Semantic proximity Read ↗

Simian virus 40 large T overcomes p300 repression of c-Myc.Semantic proximity Read ↗

Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb.Semantic proximity Read ↗

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