Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis.

Nature - 15 Mar 2001

Hasan S, Hassa P O, Imhof R, Hottiger M O

Abstract excerpt

The transcriptional coactivator p300 interacts with many transcription factors that participate in a broad spectrum of biological activities, such as cellular differentiation, homeostasis and growth control. Mouse embryos lacking both p300 alleles die around mid-gestation, with pleiotropic defect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Chromatin
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to E1A-Associated p300 Protein

Share to HeLa Cells

Share to Precipitin Tests

Share to Proliferating Cell Nuclear Antigen

Share to Trans-Activators

Source

Identifiers

PMID: 11268218
DOI: 10.1038/35066610

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11268218-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis.PMID 11268218Read ↗

The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosisSemantic proximity Read ↗

Life and death of transcriptional co-activator p300Semantic proximity Read ↗

Differential contribution of p300 and CBP to regulatory element acetylation in mESCsSemantic proximity Read ↗

Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation.Semantic proximity Read ↗

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.Semantic proximity Read ↗

CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis.Semantic proximity Read ↗

Biological role of p300 in cardiac myocytes.Semantic proximity Read ↗

p300 Alters Keratinocyte Cell Growth and Differentiation through Regulation of p21Waf1/CIP1Semantic proximity Read ↗

Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.Semantic proximity Read ↗

p300/CBP proteins: HATs for transcriptional bridges and scaffoldsSemantic proximity Read ↗

Critical roles of coactivator p300 in mouse embryonic stem cell differentiation and Nanog expression.Semantic proximity Read ↗

The Histone Acetyltransferase p300 Regulates the Expression of Pluripotency Factors and Odontogenic Differentiation of Human Dental Pulp CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.