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Article

Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1991

Templeton D J, Park S H, Lanier L, Weinberg R A

Abstract excerpt

We have examined the functional consequences of mutations present in defective alleles of the retinoblastoma susceptibility gene (RB1) isolated from two spontaneously arising tumors. Unlike cDNA clones expressing the wild-type protein p110Rb, those encoding the two mutant proteins failed to induce the appearance of senescent cells in transfected Saos-2 human osteosarcoma cells. The mutant proteins were also...

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Identifiers

PMID: 1826560
DOI: 10.1073/pnas.88.8.3033
PMCID: PMC51378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering.PMID 1826560Read ↗

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Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors.Semantic proximity Read ↗

A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.Semantic proximity Read ↗

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment.Semantic proximity Read ↗

Temperature-sensitive RB mutations linked to incomplete penetrance of familial retinoblastoma in 12 families.Semantic proximity Read ↗

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.Semantic proximity Read ↗

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