Article
Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1991
Templeton D J, Park S H, Lanier L, Weinberg R A
Abstract excerpt
We have examined the functional consequences of mutations present in defective alleles of the retinoblastoma susceptibility gene (RB1) isolated from two spontaneously arising tumors. Unlike cDNA clones expressing the wild-type protein p110Rb, those encoding the two mutant proteins failed to induc...
Topics
- Adenovirus Early Proteins
- Cell Compartmentation
- Cell Nucleus
- Humans
- In Vitro Techniques
- Mutation
- Oncogene Proteins, Viral
- Peptide Mapping
- Phosphorylation
- Protein Binding
- Recombinant Proteins
- Retinoblastoma
- Retinoblastoma Protein
- Structure-Activity Relationship
- Transfection